DETAILS, FICTION AND PXS-5153A

Listed here we show that DNL343 decreases ISR activation and neurodegeneration introduced on acutely by an optic nerve crush (ONC) injury or chronically by a germline eIF2B LOF mutation in mice. We also present that DNL343 treatment, initiated at a late stage of ailment which more precisely replicates a medical dosing paradigm, reversed these ISR a